response and recurrence rate after treatment with polyethylene glycol versus polyethylene glycol plus lactulose in children with chronic functional constipation: a randomized controlled trial

Authors

saleheh ala department of pediatrics, nemazee teaching hospital, shiraz university of medical sciences, shiraz, ir iran

mahmood haghighat department of pediatrics, school of medicine, shiraz university of medical sciences, shiraz, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

seyed mohsen dehghani department of pediatrics, nemazee teaching hospital, school of medicine, shiraz university of medical sciences, shiraz, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

hassan bazmamoun department of pediatrics, school of medicine, hamadan university of medical sciences, hamadan, ir iran; department of pediatrics, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel: +98-9121331917, fax: +98-8112667766سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

abstract

conclusions there was no significant lower recurrence rate of constipation with peg and lactulose combination therapy over peg alone. therefore, changing treatment from lactulose plus peg to peg alone would result in better compliance of patients for long-term therapy and would be cost effective. results the response rate to treatment was 70% in group i and 87% in group ii (p value 0.003). recurrence rate was 15.9% in group i and 10.3% in group ii (p value 0.3). factors such as positive family history, sex, age onset of constipation, low fiber diet, toileting and fecal incontinence did not significantly contribute to success rate of treatment or recurrence rate in the both groups. background constipation is a common symptom in children and can cause significant distress to parents. objectives the aim of this study was to investigate the response and recurrence rate after treatment with polyethylene glycol alone versus polyethylene glycol plus lactulose in children with chronic functional constipation. patients and methods in this randomized controlled trial study, 200 patients aged 1 to 12 years with functional constipation based on the rome iii criteria, were divided into two identical therapeutic groups; group i received polyethylene glycol (peg) alone and group ii received peg and lactulose. participants were treated for one month and responsive patients were followed prospectively at 3, 6 and 12 months to assess the recurrence.

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Journal title:
journal of comprehensive pediatrics

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